Jacobs syndroom

Jacobsen syndrome is caused by a deletion of genetic material at the end of the long (q) arm of chromosome 11. The size of the deletion varies among affected people, but the deleted area almost always includes the tip of chromosome 11. The specific features of Jacobsen syndrome relate to the loss of multiple genes within the deleted region Jacobs syndrome is rare male gender oriented chromosomal disorder. In human, normally 46 chromosomes are arranged and the sex determining chromosomes X and Y specifically arranged for determining male and female. In female both sex-determining chromosomes are XX and in male, detection of sex chromosomal arrangement is XY Jacobs syndrome is a genetic disorder that results in male children possessing an extra Y chromosome. Not to be confused with the XXY chromosome that causes sterility in males, this condition does not usually result in any major physical abnormalities Jacobsen syndrome is a rare congenital condition that's caused by the deletion of several genes in chromosome 11. It's sometimes called partial monosomy 11q. It occurs in about 1 in 100,000..

Jacobsen syndrome Genetic and Rare Diseases Information

  1. Many individuals are unaware of what Jacob's syndrome means, though it is easy to spot once the knowledge is there. It’s more commonly referred to as XYY Syndrome, but it’s not a common health problem. XYY Syndrome occurs when an individual does not have the typical forty-six chromosomes in their cells
  2. Males with XYY syndrome have 47 chromosomes because of the extra Y chromosome. This condition is also sometimes called Jacob's syndrome, XYY karyotype, or YY syndrome. According to the National..
  3. al deletion disorder. The deletion may range from 5 million to 16 million deleted DNA base pairs
  4. Klinefelter syndrome is a genetic condition affecting males, and it often isn't diagnosed until adulthood. Klinefelter syndrome may adversely affect testicular growth, resulting in smaller than normal testicles, which can lead to lower production of testosterone. The syndrome may also cause reduced muscle mass, reduced body and facial hair, and.
  5. Stevens-Johnson syndrome (SJS) is a rare, serious disorder of the skin and mucous membranes. It's usually a reaction to medication that starts with flu-like symptoms, followed by a painful rash that spreads and blisters. Then the top layer of affected skin dies, sheds and begins to heal after several days

Jacobs Syndrome - Symptoms, Treatment, Life Expectancy, Cause

  1. What is Jacob's Syndrome? Windowofworld.com - Jacob's Syndrome is a condition of genetic mutations that occur in men. If normally every cell in the body has 46 chromosomes, sufferers of Jacob's syndrome actually have 47 chromosomes. Although rare, but Jacob's syndrome is worth knowing
  2. 47, XYY syndrome is caused by having an extra copy of the Y chromosome in each cell of the body. The Y chromosome is one of the sex chromosomes, and the other sex chromosome is called the X chromosome. Most people have two sex chromosomes, with girls having two X chromosomes, and boys having one X and one Y chromosome
  3. Continuing Education Activity. Jacob's syndrome is a rare genetic abnormality in which a male receives an extra Y chromosome from his father. While many patients go undiagnosed due to mild symptoms, the disease does seem to confer an increased risk for certain comorbid conditions such as asthma, seizure disorders, autism spectrum disorder, learning disabilities, and behavioral problems
  4. To prevent any future confusion, it is important to know that XYY syndrome is also referred to as Jacob's syndrome or 47, XYY syndrome, YY syndrome or XYY karyotype. The names all represent the same issue, that there is an extra Y chromosome than usual. Here is a quick video explaining XYY syndrome and the myth around supermale
  5. XYY syndrome is a genetic condition in which a male has an extra Y chromosome. There are usually few symptoms. These may include being taller than average, acne, and an increased risk of learning problems. The person is generally otherwise typical, including typical rates of fertility.. The condition is generally not inherited from a person's parents but rather occurs as a result of a random.
  6. XYY syndrome is a rare chromosomal disorder that affects males. It is caused by the presence of an extra Y chromosome. Males normally have one X and one Y chromosome. However, individuals with this syndrome have one X and two Y chromosomes. Affected individuals are usually very tall. Many experience severe acne during adolescence
  7. Instead of having one X and one Y sex chromosome, those with XYY syndrome have one X and two Y chromosomes. Sex chromosome abnormalities like XYY syndrome are some of the most common chromosome..

Jacobsen syndrome is a condition caused by a loss of genetic material from chromosome 11. Because this deletion occurs at the end (terminus) of the long (q) arm of chromosome 11, Jacobsen syndrome is also known as 11q terminal deletion disorder. The signs and symptoms of Jacobsen syndrome vary considerably XYY syndrome is a genetic condition found in males only. About 1 in 1,000 boys have it. Boys with XYY syndrome — also known as 47,XYY — might be taller than other boys. Other symptoms can include problems with spoken language and processing spoken words, coordination problems, weaker muscles, hand tremors, and behavioral difficulties This video dissects Jacob's syndrome, a benign genetic condition in which males have two Y-chromosomes (genotype XYY) Surviving locked-in syndrome 09:29. When 28-year old Jacob Haendel was rushed to a Massachusetts emergency room four years ago, doctors thought the one-time chef, as young as he was, was having a. Definition. Jacobsen syndrome (JS) is a contiguous gene syndrome caused by partial deletion of the long arm of chromosome 11. The condition was first described by Jacobsen in 1973 in a family with multiple members that inherited an unbalanced 11;21 translocation derived from a balanced translocation carrier parent [].The deletion size ranges from 7 to 20 Mb [2,3]

What is Jacobs Syndrome? (with pictures

Jacobsen Syndrome: Symptoms, Causes, and Treatment

A syndrome with a 47, XXY chromosome complement, in which the subjects are phenotypically male but have seminiferous tubule dysgenesis, elevated plasma and urinary gonadotropins, variable gynecomastia, eunuchoid habitus and possibly female secondary sex characteristics. Some patients are chromosomal mosaics, with two or more cell lines of. Zooey Deschanel's Ex Jacob Pechenik Speaks Out After She Moves on with New Boyfriend Jonathan Scott. PEOPLE confirmed Zooey Deschanel has moved on with Jonathan Scott. It's new, a source said. Creutzfeldt-Jakob disease (CJD) is a rare, degenerative, fatal brain disorder. It affects about one person in every one million per year worldwide; in the United States there are about 350 cases per year. CJD usually appears in later life and runs a rapid course

How To Spot Jacob's Syndrome - HealthPrep

Jacobs syndrome. December 31, 2014. Search . Overview. A rare chromosomal genetic syndrome where the male person has an extra Y male chromosome, becoming XYY instead of normal XY (male) or XX (female). The person is male and may be mostly normal, or may suffer from minor features from excess male hormones, such as excess acne being very tall. A 13-year-old boy was diagnosed with ADHD, CD, mild intellectual disability, Tourette syndrome, and 47, XYY syndrome. As in our case, the presence of the XYY syndrome with Tourette syndrome, ADHD, CD and mild intellectual disability is the first demonstrative case Jacob's syndrome is a rare chromosomal disorder which affects males. Normally people have 46 chromosomes in each cell. In males, this typically includes one X chromosome and one Y chromosome (XY). In this genetic disorder a male have an extra copy of the Y chromosome in each of their cells (XYY)

Creutzfeldt-Jakob disease (CJD) is a rapidly progressive, invariably fatal neurodegenerative disorder believed to be caused by an abnormal isoform of a cellular glycoprotein known as the prion protein. CJD occurs worldwide and the estimated annual incidence in many countries, including the United States, has been reported to be about one case. Jacobsen syndrome Definition. Jacobsen syndrome is a rare chromosome disorder that affects multiple aspects of physical and mental development.. Description. Jacobsen syndrome is characterized by a distinctive facial appearance, some degree of mental impairment, and certain types of birth defects, especially of the heart.Other common medical complications include recurrent infections. Jacobs syndrome XYY syndrome is a aneuploidy of the sex chromosomes in which a human male receives an extra Y chromosome in each cell, hence having a karyotype of 47,XYY . XYY syndrome is also called Jacob's Syndrome , XYY-trisomy , 47,XYY aneuploidy , or Supermale syndrome

Jacob's syndrome has been widely associated with behavioural problems, in turn causing geneticists to assume they will lead to a life of aggression which is not always the case but can be fairly common. Studies show that those who do display behavioural disorders tend to be unstable, have limited concern for their actions, show little. Jacobsen syndrome is a MCA/MR contiguous gene syndrome caused by partial deletion of the long arm of chromosome 11. To date, over 200 cases have been reported. The prevalence has been estimated at 1/100,000 births, with a female/male ratio 2:1. The most common clinical features include pre- and postnatal physical growth retardation, psychomotor retardation, and characteristic facial.

The rare immunodeficiency disorder known as Job's syndrome is caused by a specific genetic mutation that both overstimulates and understimulates the human immune system, leading to harmful bacterial and fungal infections and the physical features characteristic of the syndrome, according to two independent groups of scientists, one from the National Institutes of Health (NIH) and the other. About Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How YouTube works Test new features Press Copyright Contact us Creators. Jacob's syndrome treatment market is expected to gain market growth in the forecast period of 2020 to 2027. Data Bridge Market Research analyses the market is growing at a healthy CAGR in the above-mentioned research forecast period. Increasing prevalence of a prenatal diagnosis of 47, XYY syndrome should receive genetic counselling to aid in. XYY syndrome, sometimes known as Jacobs syndrome, is a sex chromosome aneuploidy that occurs in males when there are two copies of the Y chromosome instead of the expected one Y chromosome (figure 1). It is a chromosomal condition occurring in at least 1 in every 100

The 47,XYY sex chromosome variation is the most common sex chromosome anomaly after Klinefelter syndrome (47,XXY), 1 - 3 occurring in approximately 1 out of 1000 live male births. 4, 5 Parental nondisjunction at meiosis II resulting in an extra Y chromosome produces a 47,XYY karyotype in the affected offspring. 6 - 8 46,XY/47,XYY mosaics from parental nondisjunction during cell division. XYY syndrome. XYY Syndrome (symptoms) Xyy syndrome (develop) How many boys have this. How many chromosomes does a normal pers. Might be taller, coordination problems, spoken language , proc. Adhd, autism , explosive temper, impulsivity, develop low self. 1 in a 1,000. 46 in each cell divided into 23 pairs

Genetics and Man

XYY Syndrome: Causes, Symptoms, and Mor

XYY syndrome first appeared in the medical literature in 1962, eight years before Royce published his book. A team of researchers from Roswell Park Medical Institute in Buffalo, N.Y., described the first XYY person on record, a 44-year-old man who had undergone genetic testing because one of his children had Down syndrome Surviving locked-in syndrome: How one man confounded expectations of death. Ship hunts foreign ships doing work reserved for US crews. Tens of thousands evacuated as typhoon In-fa makes landfall.

Jacobsen syndrome - Wikipedi

The Jacobsen syndrome is a clinically characteristic disorder due to deletion of the terminal band 11q23. This band is known to harbor a heritable folate-sensitive fragile site (Sutherland and Hecht, 1985).The disorder was first observed by Jacobsen et al. (1973).. In a 45,X male with a translocation (Y;11)(q11.2;q24), Van Hemel et al. (1992) found features characteristic of Jacobsen syndrome. Jacobs Syndrome. By: regina • Research Paper • 776 Words • February 10, 2010 • 750 Views. Page 1 of 4. Join now to read essay Jacobs Syndrome. Jacob’s syndrome 2 Anatomy and Physiology: Jacob’s syndrom Jacob's syndrome is a rare chromosomal birth defect that affects when a male infant is born with an extra Y chromosome also called as XYY syndrome, XYY karyotype. Those patients having one X and Y syndrome gets affected with jacob's syndrome with one X and two Y chromosomes Jacobsen syndrome (also known as the chromosome 11q deletion syndrome) is a rare chromosomal anomaly that results from deletion of the terminal region of chromosome 11. It results in intellectual disabilities, a distinctive facial appearance and a variety of physical problems including heart defects and bleeding diathesis Robinson DO, Jacobs PA. The origin of the extra Y chromosome in males with a 47,XYY karyotype. Hum Mol Genet. 1999 Nov;8(12):2205-9. Citation on PubMed; Ross JL, Roeltgen DP, Kushner H, Zinn AR, Reiss A, Bardsley MZ, McCauley E, Tartaglia N. Behavioral and social phenotypes in boys with 47,XYY syndrome or 47,XXY Klinefelter syndrome

Forgotten Voice - XYY - YouTube

Le syndrome de Jacob est apparenté au syndrome de klinefelter. Il est souvent responsable d'un retard mental, et d'un trouble de comportement. Le phénotype XYY comprend une avance staturale, macrocéphalie, clinodactylie, hypotonie et un hypertélorisme Jacobs syndrome is a rare chromosomal disorder that affects only males. It is a condition where there is the presence of an extra Y chromosome in all of a male's cells. Males normally have only one X and one Y chromosome, however, individuals with Jacob's syndrome have at least one X and at least two Y chromosomes (XYY) Jacob's syndrome (XYY Syndrome) By: Maryam Azab This condition occurs in about 1 in 1,000 newborn boys. All males are at the same risk of having this disorder because it is not inherited, it is a random mistake that occurs during meiosis. Men with XYY Syndrome can—and very ofte

Klinefelter syndrome - Symptoms and causes - Mayo Clini

..XYY Syndrome, Jacob Syndrome XYY Syndrome, better known as the Jacob Syndrome is a rare genetic disorder which affects males due to an extra Y chromosome. Healthy males have 46 chromosomes including one X and one Y chromosome. Men with XYY syndrome have 47 chromosomes, two of which are Y chromosomes. It is not known why the extra Y chromosome occurs. The disorder is present at birth and is. Jacob's syndrome is a rare chromosomal birth defect that affects when a male infant is born with an extra Y chromosome also called as XYY syndrome, XYY karyotype. Those patients having one X and. Jacob's Williams Syndrome Fundraiser, Swansea. 1.3K likes. Support Mark's 85 Mile Walk to fundraise for families affected by Williams Syndrome

By linkage studies in 4 kindreds with autosomal recessive camptodactyly-arthropathy-coxa vara-pericarditis syndrome, Suwairi et al. (1997) and Bahabri et al. (1998) demonstrated that all patients were homozygous for a contiguous series of markers on 1q, compatible with homozygosity by descent. Affected patients from 2 of the 4 kindreds (both from Saudi Arabia) had an identical haplotype within. The jacob's syndrome treatment market is segmented on the basis of type of test, treatment, route of administration, end-users and distribution channel. The growth amongst the different segments helps you in attaining the knowledge related to the different growth factors expected to be prevalent throughout the market and formulate different.

Superman syndrome, also known as 47, XYY, is a condition classified as a chromosomal aneuploidy (which is an abnormality in chromosome structure and/or number) in which males have an additional Y. Symptoms. Males with Jacob's Syndrome are suspected to be at a higher risk for learning disabilities, delays in speech, early language skills, and motor skill development. They might also suffer from low muscle tone, involuntary movements, behavior and/or emotional difficulties, acne, swollen joints, arthritis, stiff joints, difficulty moving. Background A rare progressive supranuclear palsy-like syndrome seemingly triggered by aortic surgery was first described in 2004. This largest case series to date describes the features of this syndrome. Methods We searched the Mayo Clinic electronic medical records using the advanced cohort explorer search engine for patients evaluated for neurologic symptoms after cardiac-aortic surgery in. XYY Syndrome Association of Australia Inc. Creating awareness for XYY Syndrome by obtaining and providing the latest research for XYY families and the community. Networking with government services, medical specialists, general practitioners and educators to create a better understanding for

Stevens-Johnson syndrome - Symptoms and causes - Mayo Clini

Read my story featured in The Guardian, or listen to the Guardian podcast.Follow my progress on YouTube . Hello, my name is Jacob Haendel and I am 32 years-young. While my ongoing recovery from locked-in syndrome and Toxic Progressive Stage 4 Leukoencephalopathy doesn't define who I am, it has consumed my life for the past four years Jacobsen Syndrome, also known as Chromosome 11q Deletion Syndrome, is a rare chromosomal disorder. In this syndrome, there is a loss of genetic material in the long arm of chromosome 11 Approximately (and only) 5-10% of individuals with Jacobsen Syndrome (JBS) have a family history of the condition

Rare Reflections: Jacob's Story. Posted by Valaree DonFrancesco. I was diagnosed with toxic acute progressive leukoencephalopathy, a rare brain disease that took me from a high functioning and able-bodied individual to locked in syndrome, in six months. This story began on May 24, 2017 at UMass Memorial Hospital in Worcester Massachusetts The signs and symptoms of Jacobsen syndrome differ from person to person. Most often people with this syndrome are seen to have a bleeding disorder called Paris-Trousseau syndrome, specific facial features, slowed development of speech/motor skills and cognitive impairment/learning problems.Some of the other symptoms include congenital heart problems, attention deficit hyperactivity disorder. Jacobsen syndrome or JBS, named after the Danish physician Petra Jacobsen who first identified and described it 1973, is a rare condition characterized by the loss of genetic material from the tip of the long arm (q) of chromosome 11. Hence, the condition is often called chromosome 11q deletion syndrome/disorder or partial 11q monosomy syndrome

Jacob's Syndrome: Causes, Symptoms and Treatment - Window

Help is available. Creutzfeldt-Jakob Disease Foundation is a nonprofit organization that offers support, information and guidance to those dealing with Creutzfeldt-Jakob disease. Call the Foundation at 800.659.1991. The Alzheimer's Association can help you learn more about Alzheimer's and other dementias, and help you find local support services. Call our 24/7 Helpline at 800.272.3900 My nephew Jacob is part of the one to nine out of every 100,000 people who have Sotos Syndrome. Basically, it is a form of gigantism. The rapid growth can cause issues, such as a dilated aorta, gives his face a particular shape and is assorted with various learning disabilities

The Jacobs' syndrome consists in the presence of a Y chromosome in excess. The prevalence of XYY sex chromosome abnormalities in newborns is as high as 1:1000, but they are often unidentified because they are not necessarily associated with gross physical or cognitive impairments, and so they may never come to medical attention Jacob was born with Down Syndrome and was later diagnosed with Autism as well. However, Nancy, her husband, Dale, and Jacob's two older siblings, Katy and Hunter, don't see either of his diagnoses as a hindrance to his life or theirs

Peggy Jo Jacobs - IMDb

Jarcho-Levin syndrome is a genetic birth defect which causes malformed bones in the spine (vertebrae) and ribs. Infants born with Jarcho-Levin syndrome have short necks, limited neck movement, a short stature, and difficulty breathing, due to small, malformed chests that have a distinctive crab-like appearance JacobsConnect is loading - thank you for your patience. Be sure to visit our JacobsConnect Help & Support space to learn more about using our intranet (Sweet´s Syndrome) History Sweet's Syndrome (Acute Febrile Neutrophilic Dermatosis) has been first described by the English dermatologist Robert Douglas Sweet from Plymouth in 1964 following the observation of 8 female patients.The disease has been commonly termed Sweet's Syndrome, afterwards, and experienced increasing awareness during the last ten years Jacob's Hope is a clinic for newborns who are suffering with Neonatal Abstinence Syndrome, or withdrawals from pre-natal exposure to drugs. Our medically nurturing facility cares for these infants while the drugs leave their systems. We love and care for these babies in a home-like environment until they are ready for discharge

47, XYY syndrome Genetic and Rare Diseases Information

Jacob's Syndrome is where there is an extra copy of the Y chromosome. This can lead to learning disabilities and delayed development of speec Peutz-Jeghers syndrome (PJS) is a condition where people develop characteristic polyps and dark-colored spots and have an increased risk of certain types of cancer. The gene that is mutated, causing this condition, is responsible for controlling cell growth. People with PJS can develop polyps — called Peutz-Jeghers polyps — in the small.

Jacob syndrome 1. JACOBSYNDROME 2. WHAT IS JACOBSYNDROME? Jacobs syndrome is a rare chromosomal disorder that affects males. It is caused by the presence of an extra Y chromosome. 3. Males normally haveone X and one Ychromosome.However, individualswith Jacobs syndromehave one X and two Ychromosome. 4 Klinefelter syndrome, also known as XXY syndrome, is a condition in boys and men that's caused by an extra X chromosome. It can affect physical and mental development HELLP, a syndrome characterized by hemolysis, elevated liver enzyme levels and a low platelet count, is an obstetric complication that is frequently misdiagnosed at initial presentation. Many.

Jacobs Syndrome Article - StatPearl

What is XYY Syndrome (47) ? Causes, Symptoms and Diagnosi

XYY syndrome - Wikipedi

Klinefelter syndrome (KS) or 47,XXY syndrome is a variation of intersex affecting approximately 1/500 AMAB/CTM individuals, making it one of the most common chromosomal variations of intersex.1 It results from having two or more X chromosomes and one Y chromosome (XXY) rather than just XY. Symptoms may include greater height, poor coordination, less body hair, decreased ability to gain muscle. Define Jacod's syndrome. Jacod's syndrome synonyms, Jacod's syndrome pronunciation, Jacod's syndrome translation, English dictionary definition of Jacod's syndrome. n. 1. A group of symptoms that collectively indicate or characterize a disease, disorder, or other condition considered abnormal. Jacobs Aletta; Jacobs Helen Hull; Jacobs Jane. Surviving locked-in syndrome: How one man confounded expectations of death. When 28-year old Jacob Haendel was rushed to a Massachusetts emergency room four years ago, doctors thought the one-time chef, as young as he was, was having a stroke. But he wasn't; his scans showed something very different, and very strange: Jake's brain seemed to. Asperger's syndrome is a neurological disorder in the family of autism spectrum disorders. Because every child exhibits a different set of symptoms, there is no precise checklist of behaviors that. The first case of XYY syndrome was reported as an incidental finding by Adam Sandberg and colleagues in 1961. Four years later, Patricia Jacobs, a British geneticist, further researched this chromosome aneuploidy and described it in great detail; thus, the presence of an extra Y chromosome is also called Jacob's syndrome

XYY Syndrome - NORD (National Organization for Rare Disorders

A condition in which a male best friend of a girl is in love with said girl, but is constantly shot down or ignored in favor of other men. When he does finally get a chance to admit his feelings, he is most often rejected in favor of being 'just friends' and will never get a chance to be with the girl again. There is no cure for Jacob Syndrome except to somehow find a girl you are even more in. Jacobs found that 1 in 28 of these subjects were XYY. This high rate, compared with the incidence in the general population, seemed to suggest that the XYY condition could indeed be linked to increased violent or antisocial behavior. Studies of other similar populations confirmed Jacobs's findings An example of this would be a child with unbalanced translocation down syndrome. One of the child's parents is a carrier of Balanced Robersonian Translocation. Since the karyotype is 46 XY der (14,21) (q10,q10) +21, the child must have gained one extra chromosome No.21 Jacob's Story, as told by his mom, Teri: Jacob is my 25 year old son with UPD PWS. Thankfully PWSA has been there for us since Jacob was born. We have definitely had challenges over the years. Those teenage years were filled with behaviors so we tried an ISL (independent supported living) in Kansas City, MO but it didn't work out Annie Jacob started volunteering with the local Angelman Syndrome Foundation walk, which will help raise money to support families with therapies and resources. Ryan Jacob now serves on the board for the Foundation for Angelman Syndrome Therapeutics. Ryan Jacob says there are pharmaceutical companies doing research and starting clinical trials

What Is XYY Syndrome? Symptoms, Causes, Diagnosis

Category filter: Show All (35)Most Common (0)Technology (0)Government & Military (3)Science & Medicine (12)Business (8)Organizations (22)Slang / Jargon (0) Acronym Definition JBS John Birch Society JBS Judge Business School (University of Cambridge; UK) JBS Japan Bible Society (est. 1937) JBS Joint British Societies (UK) JBS Journal of Biosocial Science. Following are some celebrities and famous people with klinefelter syndrome: 1. George Washington. George Washington, the once President of the United States was rumored to have been affected by klinefelter's syndrome. He did not have any biological children but only 2 adopted ones with his wife Martha Takotsubo cardiomyopathy, also called broken-heart syndrome, is a weakening of the left ventricle that is usually the result of severe stress. Its symptoms resemble those of a heart attack, and treatment is usually the same as that for heart failure

Jacobsen syndrome: MedlinePlus Genetic

Video: XYY Syndrome (for Parents) - Nemours Kidshealt

Sporadic Creutzfeldt–Jakob disease | Image | RadiopaediaXYY Syndrome - Who's there film challenge (2013) - YouTube

As a popular advice columnist in the UK, Barbara Jacobs never suspected she'd be the one needing the relationship advice. But when she fell in love with Danny, a man with Asperger's Syndrome, she quickly learned to expect the unexpected. In this book, Barbara candidly delves into the dynamics of their relationship Guillain-Barré syndrome Hugh J Willison, Bart C Jacobs, Pieter A van Doorn Guillain-Barré syndrome is the most common and most severe acute paralytic neuropathy, with about 100 000 people developing the disorder every year worldwide. Under the umbrella term of Guillain-Barré syndrome are severa Ryan and Annie Jacob's son 2-year-old Grayson was diagnosed last year with the syndrome. Ryan Jacob now serves on the board of the foundtation, which focuses on funding research into treatments Journal of Medical Case Reports BioMed Central Open Access Case report Goodpasture's syndrome with positive C-ANCA and normal renal function: A case report Arunachalam Ramaswami*1, Thiraviyam Kandaswamy1, Tholappan Rajendran1, Hla Aung1, Chakko K Jacob1, Haji Shaukat Zinna1 and Pemasiri Upali Telesinge2 Address: 1Department of Nephrology, RIPAS Hospital, Brunei Darussalam and 2Department of. The arrest of former South African President Jacob Zuma this month has triggered looting and violence in the country's two most populous provinces amid a record wave of Covid-19 infections