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Latex agglutination test bacteria

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The Wellcogen™ Bacterial Antigen Kit provides a series of rapid latex tests for use in the qualitative detection of antigen from Streptococcus group B, Haemophilus influenzae type b, Streptococcus pneumoniae (pneumococcus), Neisseria meningitidis (meningococcus) groups A, B, C, Y or W135 and Escherichia coli K1 present in cerebrospinal fluid (CSF) as a consequence of infection A simple and rapid latex agglutination test (LAT) has been developed for detecting rabies virus (RABV) antigens in saliva. Latex particles are coated with anti-rabies antibody. The antibody-coated particles are specifically agglutinated by RABV, and the agglutination is evident macroscopically within minutes Everything You Should Know About Latex Agglutination Tests. 22 November 2018 Agglutination is the process that occurs when an antigen is mixed with its corresponding antibody called agglutinin and is commonly used in blood grouping.. Latex agglutination testing, also called latex fixation, is a diagnostic study that is widely used as a laboratory method to identify certain antibodies and antigens

Latex Agglutination Test Principle. The latex agglutination test is based on a reaction between latex beads and a specific antibody or antigen. So an example of saliva, blood or urine are taken to the lab, and in the lab, they are getting mixed with these latex beads coated with this specific antibody or antigen Last updated on May 29th, 2021. When the specific antibodies (agglutinins) bind to surface antigens of bacteria, virus, or any antigens immobilized in particulate matter (such as latex particle) and cause the formation of visible clumps, such test is called agglutination test The latex agglutination test is a clinical method to detect certain antigens or antibodies in a variety of bodily fluids such as blood, saliva, urine or cerebrospinal fluid. The sample to be tested is sent to the lab and where it mixed with latex beads coated with a specific antigen or antibody A modified latex agglutination (LA) test was compared with Gram-staining and counterimmunoelectrophoresis (CIE) for the rapid detection in the cerebrospinal fluid (CSF) of antigen to Haemophilus influenzae type b, Neisseria meningitidis groups A, B and C, Escherichia coli K1, Streptococcus pneumoniae and group B streptococci, seven frequent causes of bacterial meningitis in children that the test will not be widely used in the diagnOSIs of disease. Various techniques have been dev· eloped for the detection of bacterial toxins. The easiest and most eco­ nomical method which does not require special equipment IS that based upon the agglutination of preserved erythrocytes or latex particles as a reaction Indicator

Agglutination of white latex particles is visible to the unaided eye within 60 seconds and represents a positive reaction. Use with suspected S. aureus colonies. Prior to testing, suspect colonies should be Gram stained and a catalase test performed to verify that they are Staphylococcus This study assessed the contribution of latex agglutination (LA) tests to the diagnosis of bacterial meningitis. Researchers reviewed data from 176 consecutive pediatric inpatients, 2 weeks to 16 years old, who underwent lumbar puncture during a one-year period. At least one LA test was ordered for 161 of the patients, and a total of 610 LA. Diagnostic evaluation of latex agglutination test and study of spectrum of bacterial pathogen in neonatal meningitis IOSR-JMDS , 7 ( 4 ) ( 2013 ) , pp. 57 - 62 Google Schola

Agglutination of latex beads in indirect agglutination assays can be used to detect the presence of specific antigens or specific antibodies in patient serum. The presence of some antibacterial and antiviral antibodies can be confirmed by the use of the direct Coombs' test , which uses Coombs' reagent to cross-link antibodies bound to red. The method developed by Lancefield is a direct agglutination assay, since the bacterial cells themselves agglutinate.A similar strategy is more commonly used today when identifying serovars of bacteria and viruses; however, to improve visualization of the agglutination, the antibodies may be attached to inert latex beads.This technique is called an indirect agglutination assay (or latex.

Latex Agglutination Test Immunology Microbe Note

Transcribed image text: StaphTEX Agglutination Reaction Pre-Lab: Ensure that you have read all the introductory material in the Lab Manual (starting on page 229) AND in the Pre-Lab section of this lab module! . . Materials: Hardy StaphTEX Blue Kit: 0 Reagents O Wooden Sticks Latex Agglutination Cards Disposable inoculating loops Unknown bacterial cultures (A&B) 0 Hardy StaphTEX Blue Kit. agglutination Lab medicine The clumping of aggregates of antigens or antigenic material-eg bacteria, viruses, with antibodies in a solution. See Latex agglutination test Reproductive biology The conjoining of 2 organisms of the same species for sexual reproduction, which may be mediated by a carbohydrate on one organism and a protein on the other, thereby forming a glycoprotein Latex Agglutination Kits HiMedia offers, Hi-Latex series of rapid diagnostic kits based on slide latex agglutination. These tests depend on the agglutination of antibody coated latex particles with antigens from corresponding microorganisms from various sources such as biological fluids from patients, liquid broth media etc In a latex agglutination test, a sample is mixed with latex beads coated with antibodies.Majority of pathogenic streptococci possess specific carbohydrate antigens, which permit the classification of streptococci into groups.These streptococcal group antigens can be extracted from the cells and their presence demonstrated with latex particles previously coated with group-specific antibodies

Latex agglutination test: MedlinePlus Medical Encyclopedi

Thevalue ofthe latex agglutination test in meningitis was assessed. This was positive in 60% cases of Streptococcus pneumoniae, 93% of Haemophilus Bacterial meningitis in childhood carries The E. coli O157 Test is a rapid latex agglutination test, designed solely for the presumptive identification of Escherichia coli serogroup O157:H7 cultured on Rainbow agar plate. The Test Kits could be used as part of the USDA-FSIS test protocol described in the USDA-FSIS Microbiology Laboratory Guidebook (MLG) Chapter 5 Detection, Isolation and Identification of Top Seven Shiga-Toxin.

[Latex agglutination tests of the cerebrospinal fluid in

  1. Latex agglutination test is also known as the latex fixation test. Clinically this test is used for the identification and typing of many important microorganisms. In 1965, Singer and Plotz first introduced this test and was described as the Rheumatoid Factor Test, which is based on the latex agglutination
  2. Penicillin-Binding Protein (PBP2/) Latex Agglutination Test 1. INTENDED USE This test is a rapid latex agglutination assay, detecting PBP2/ (also called PBP2a)7, in isolates of Staphylococcus, as an aid in identifying methicillin-resistant Staphylococcus aureus (MRSA) and methicillin- resistant coagulase-negative staphylococci
  3. The main purpose of the Latex agglutination test is to detect the presence of antibodies produced against a particular antigen or virus or bacteria. Specimen collection Agglutination test used in all types of body fluids to detect antigens and antibodies, for example, Saliva, Urine, Blood, Cerebrospinal fluid (lumbar puncture)
  4. Bacterial agglutination is often used as a quick test for. identification of bacteria and is very specific. antibodies are mixed with bacteria and if the antibodies bind to proteins on the surface of the bacteria visible clumps will form. In direct agglutination. agglutination colored latex beads covered with antigen and mixed with antibodies

latex agglutination assays that could be used as a one-step, 10-minute assay to confirm the presence of E. coll from any primary culture, enrichment broth or colony on a petri plate. In addition, the latex agglutination assays might be used to rapidly identify E. coli that are eithe Wellcogen Latex Agglutination Test for Bacterial Antigen (PHADEBACT) Wellcogen Latex Agglutination Test for Bacterial Antigen (PHADEBACT) is use to detect qualitative strep group B antigen from CSF and urine samples, H. influenzae Type b, Streptococcus pneumoniae, Neisseria meningitis groups A,B,C,Y or W135, E. coli K1 present in the CSF.. In agglutination tests (eg, latex agglutination, coaggregation), very small particles (latex beads, gelatin particles, bacteria) are coupled to a reagent antigen or antibody. The resulting particle complex is mixed with the specimen (eg, cerebrospinal fluid, serum); if the target antibody or antigen is present in the specimen, it cross-links. means of testing for bacterial toxins, they do not provide information on the biological activity of the toxin. Thus, latex agglutination (RPLA) can be used to detect soluble antigens in food extracts or culture filtrates by a simple latex agglutination assay. In a conventional agglutination test, sol. The detection employs the latex agglutination test, where functionalized latex particles form agglutinates with specific antigens in the fluid sample. Channels fabricated using adhesive tapes coated with hydrophilic materials are used to drive the fluid sample through a detection zone, where an image analysis algorithm quantifies the degree of.

Video: The latex agglutination test versus

Conclusion: Bacterial meningitis is the commonest cause of morbidity and mortality.Haemophilus influenza type b being the commonest organism.CSF LAT is a good sensitive test to detect bacterial meningitis early with sensitivity of 77.8%. Key Words: Bacterial Meningitis, CSF Latex Agglutination Test. Introductio Latex Agglutination Test Principle -Antibody molecules are bound to latex beads. -If antigen is present in test serum, it will bind with the antibodies forming cross-linked aggregates This test is performed for the diagnosis of an autoimmune disease known as Rheumatoid Arthritis (RA). This disease affects synovial joints (like joints of hands, knees, and feet) with subcutaneous nodules. The prevalence rate is 1% (women are affected 3-5% more). There are evidence of RA (Rheumatoid Arthritis) disease in smoker people than non-smokers.Rheumatoid factor (RF) is circulating in. Gram stain, culture and latex agglutination test (LAT) of cerebrospinal flud were performed in 50 patients clinically diagnosed as suffering from pyogenic bacterial meningitus. Using all the three techniques, an aetiological diagnosis was made in 27 (54%).Neisseria meningitidis, Streptococcus pneumoniae and H. influenzae were the infecting organisms in 21 cases (44%)

1.1 Latex particle Agglutination Test (LAT) Latex agglutination test is simple to perform and very useful for rapid diagnosis of bacterial antigen in CSF. The test uses the technique of absorbing antiserum for specific antigen onto latex particles of uniform diameter, generally 0.8 microns An indirect latex agglutination test for the detection of an antibody in a biological sample. This works based on similar principles whereby antigens of the antibody corresponding are bound to latex particles (Fig. 1). This approach is applicable to mono- and polyvalent antigens, e.g., drugs, steroid hormones, and proteins

Wellcogen™ Bacterial Antigen Rapid Latex Agglutination

bacteria. For example, the Widal test, used for the diagnosis of typhoid fever, looks for agglutination of Salmonella enterica subspecies typhi in patient sera. The Widal test is rapid, inexpensive, and useful for monitoring the extent of an outbreak. (OpenStax CNX, 2018) We will use latex agglutination to test for the presenc However, conventional agglutination tests only provide presumptive results. Here I describe and perform a latex agglutination test (LAT) that can detect and quantify L. pneumophila in a sample by determining the degree of agglutination. The latex microbeads (beads) are coated with polyclonal antibodies using established methods Conventional latex agglutination (LA) enables rapid detection of bacterial antigen in cerebrospinal fluid (CSF) (1, 2) and can also be used to test specimens of blood (3,4) or urine and for serogroup determinations on primary cultures (6, 7). We discuss here test-card agglutination and also describe a new technique based upon LA in an. In addition to causing precipitation of soluble molecules and flocculation of molecules in suspension, antibodies can also clump together cells or particles (e.g., antigen-coated latex beads) in a process called agglutination (Figure 18.9). Agglutination can be used as an indicator of the presence of antibodies against bacteria or red blood cells

The BBL™ Staphyloslide ™ Latex Test consists of blue latex particles coated with human fibrinogen and IgG. On mixing the latex reagent with colonies of staphylococci which have clumping factor or Protein A present, cross-linking will occur giving visible agglutination of the latex particles. Such agglutination will occur notably with S. aureus E.g. Antigens coated in latex particles used in ASO test. When the antibody instead of antigens is adsorbed on the carrier particle for detection of antigens, it is called reverse passive agglutination. Latex Agglutination: It employs latex particles as carrier of antigen or antibodies. In latex agglutination, many antibody or antigen molecules. One detached in the latex agglutination test; however, when this test was group joined all isolates identified as S. oralis by MLSA (marked by repeated, indolent agglutination took place for 12 isolates both in filled circles on Fig. 1) including both isolates determined as S. oral- the samples under study and in negative control, so we could. In combination with a clinical picture and CSF examination consistent with bacterial meningitis, a presumptive diagnosis of bacterial meningitis caused by N. meningitidis, S. pneumoniae, or H. influenzae can be made after performing a Gram stain of the CSF sediment or by detection of specific antigens in the CSF by a latex agglutination test or using RDTs A modified latex agglutination (LA) test was compared with Gram-staining and counterimmunoelectrophoresis (CIE) for the rapid detection in the cerebrospinal fluid (CSF) of antigen to Haemophilus influenzae type b, Neisseria meningitidis groups A, B and C, Escherichia coli K1, Streptococcus pneumoniae and group B streptococci, seven frequent causes of bacterial meningitis in children. Of 50 CSF.

Latex Agglutination Test - an overview ScienceDirect Topic

  1. Various methods of agglutination are used in diagnostic immunology and these incude latex agglutination, flocculation tests, direct bacterial agglutination, and hemagglutination. In latex agglutination, many antibody molecules are bound to latex beads (particles), which increases the number of antigen-binding sites. If an antigen is present in.
  2. Description. Rapid and accurate latex test for the identification and differentiation of staphylococcus aureus. White latex particles are coated with human fibrinogen for detection of clumping factor and specific IgG for detection of protein A. Flexible use from selective and non-selective media (Blood Agar, Columbia CNA, Baird Parker, etc.
  3. utes. The degree.
  4. Staphylococcus aurous Staphylococcus epidermis Control latex Text latex Control latex Text latex #1 #1 12 ☺ ☺ OO Fill in the chart. Summarize the results of your observations of the coagulase test Bacterial sample Agglutination (Yes or No) Coagulase (+ or -) 1. Staphylococcus aureus 2. Staphylococcus epidermis Short Answer
  5. detection of this VT with a Vero cell test or a VT immunoassay can provide evidence of infection in the absence of a culturable VTEC. In this study we used the Vero cell assay to evaluate an experimental Reversed Passive Latex Agglutination (RPLA) assay for the detection of VT in bacterial culture supernatant fluids and patients' faeces
  6. utes confirms that the ASO title is above 200 IV. 5. Widal Test: Widal test is a diagnostic test for typhoid. The causative agent of typhoid is Salmonella typhi. The test is based on antigenic reaction of the bacteria. Principle: The killed bacterial suspension of Salmonella carries specific o and H antigens

Everything You Should Know About Latex Agglutination Tests

Latex Agglutination Test: Procedure, Principle,Types

Rheumatoid factor latex agglutination • 2. Bacterial latex agglutination • 3. Coombs test • 4. Blood typing 14. Agglutination In this test the antigen is particulate (visible, big and insoluble) (e.g. bacteria and red blood cells) or an inert particle (latex beads) coated with antigen 3 [EN] 1. INTENDED USE Pastorex™ Meningitis assay is an agglutination test intended for the rapid diagnosis of bacterial meningitis by: • The qualitative detection of soluble antigens to Neisseria meningitidis groups A, B/E. coli K1, C, Y/W135, Haemophilus influenzae type b, Streptococcus pneumoniae and group B Streptococcus, in cerebrospinal fluid (CSF) an Agglutination is the process whereby specific antigens (e.g., red blood cells) aggregate to form larger visible clumps when the corresponding specific antibody is present in the serum. Figure 10-1 Agglutination patterns. A, Slide agglutination of bacteria with known antisera or known bacteria The Slidex Staph reagent is a combination agglutination test based on latex and hemagglutination components that detect bound coagulase, protein A, and specific S. aureus cell surface antigens. This reagent includes blood cells sensitized with fibrinogen to detect bound coagulase and latex particles sensitized with specific monoclonal antibodies

PROCEDURE. Mix the bottles of test and control reagent well. Pick up several colonies of test bacteria and smear onto a well on the card supplied. Place a drop of each reagent onto the bacteria and mix with a clean toothpick. Rock the card gently and observe for visible clumping or agglutination of the latex particles Recently, a latex agglutination (LA) test (Marion Laboratories) for rapid diagnosis of CAC has become available. Although early evaluations have been favorable, new evidence suggests that the LA reagent binds a soluble bacterial antigen that is not unique to toxigenic strains of C. difficile ABSTRACT. Francisella tularensis are highly infectious bacteria causing a zoonotic disease called tularemia. Identification of this bacterium is based on antigen detection or PCR. The paper presents a latex agglutination test (LAT) for rapid identification of clinically relevant F. tularensis subspecies. The test can be performed within three minutes with live or inactivated bacteria Rapid latex agglutination test for direct detection of 30 tests R30859203 bacterial antigens to Neisseria meningitidis A, C, Y, W135 present in body fl uids and blood cultures. Wellcogen Neisseria meningitidis B/E.coli K1 Rapid latex agglutination test for direct detection of 30 tests R30859502 bacterial antigens to Neisseria meningitidis Gp

Agglutination Tests: Types, Principle, Uses • Microbe Onlin

Latex Agglutination (Theory) : Immunology Virtual Lab I

  1. suspensions of latex beads with rabbit antibody specific for S. pneumoniae capsular antigens. Visible agglutination occurs when the S. pneumoniae capsular antigen reacts with the antibody-coated latex beads. The manufacturer's instructions should be followed precisely when using these kits
  2. A latex fixation test, also called a latex agglutination assay or test (LA assay or test), is an assay used clinically in the identification and typing of many important microorganisms.These tests use the patient's antigen-antibody immune response. This response occurs when the body detects a pathogen and forms an antibody specific to an identified antigen (a protein configuration) present on.
  3. Plasma must not be used since fibrinogen may cause non-specific agglutination of the latex. It is preferable to test samples on the same day as collected. Serum samples may be stored at 2-8°C for up to 48 hours prior to testing. If longer storage is necessary, sera should be stored frozen at -20°C. Materials used in the ASO Test
  4. J. clin. Path., 1972, 25, 1079-1082 Latex agglutination in the diagnosis ofmeningococcal meningitis W. P. J. SEVERIN From the Department ofBacteriology, the Laboratory ofHygiene, Municipal University ofAmsterdam, Netherlands SYNOPSIS Group-specific polysaccharides of Neisseria meningitidis groups Aand C have been demonstrated bymeansofarapid, sensitive slide agglutination test withlatex.

BactiStaph™ Latex Agglutination Test Ki

(a) Latex particles were sensitized in the usual manner with immunopurified antiH-LT (1:20) and then used to titrate purified HLT as described in Table 1. (b) --, No agglutinization at any level of HLT. EXAMPLE 4. The rapid agglutination test of the present invention was evaluated with bacterial colonies on different media If using O157 latex reagents, it is important to test isolates in the control latex to detect nonspecific agglutination of organisms with latex. Manufacturers of O 157 latex reagents recommend heating strains that agglutinate in the latex control reagent and then retesting them in both the O157 antibody-coated and control latex reagents Applications of agglutination include A-B-O blood typing tests and rapid bacterial identification. The microtiter test is used to quantify the amount of antibody in patient's blood. Part 1. Rapid Slide Agglutination In this lab exercise, you will learn how to use rapid slide agglutination to determine your blood type Rapidly detect and presumptively identify Salmonella from culture by latex agglutination using Thermo Scientific™ Wellcolex™ Color Salmonella Rapid Latex Agglutination Test Kit. Save up to two days' testing time over traditional screening procedures with this easy-to-use, cost-effective test Advantages. Results available in 20 minutes. IV. Efficacy. Test Specificity: High. Test Sensitivity: Low overall (does not rule-out Bacterial Meningitis) Haemophilus Influenza e Type B: 60-100%. Low sensitivity for Neisseria Meningitidis

Latex Agglutination Tests for Bacterial Meningitis

The latex agglutination test is less sensitive for Neisseria More Details meningitidis. The kit based latex agglutination tests do not detect meningitis due to pathogens like Listeria monocytogenes , Staphylococcus aureus , Enterobacteriaeceae members other than Escherichia More Details coli and Mycobacterium tuberculosis Counterimmunoelectrophoresis (CIE) for rapid diagnosis by antigen detection in cerebrospinal fluid has been used for some time but results are often poor in patients whose fluids are culture negative. Latex beads coated with specific antibody (LA) are technically easier to use and reported results indicate that the test is more sensitive than CÍE

Latex Agglutination Test (LAT) - For rapid diagnosis of

  1. Microgen Campylobacter Latex. A latex agglutination test for the presence of Campylobacter spp on solid media or in enrichment broths.These assays are designed to provide simple, one step identification / confirmation of Camplylobacter.Immediate results detect presence of Camplyobacter, can be used in clinical, food, environmental and water testing laboratories
  2. A latex agglutination confirmation test for the presence of Salmonella spp on solid media from clinical and food samples. Accurate enough to screen positives from 24 hour enrichment broths. Detects motile and non motile strains. Reduces testing delays associated with conventional methods
  3. Abstract. A modified latex agglutination (LA) test was compared with Gram-staining and counterimmunoelectrophoresis (CIE) for the rapid detection in the cerebrospinal fluid (CSF) of antigen to Haemophilus influenzae type b, Neisseria meningitidis groups A, B and C, Escherichia coli K1, Streptococcus pneumoniae and group B streptococci, seven frequent causes of bacterial meningitis in children
  4. 2. PASTOREX TM STAPH-PLUS, 5 x 50 test kit, code 56353 • Latex test: test reagent, 5 dropper bottles (1 ml). • Negative control: negative control reagent, 5 dropper bottles (1 ml). • Disposable agglutination cards, 4 x 16 • Rods, 3 x 100 5- STORAGE Once open, all reagents are stable until the expiry dates indicated on th
  5. A rapid, color enhanced latex agglutination test to detect clumping factor and/or Protein-A, characteristics associated with Staphylococcus aureus colonies obtained from culture. Color enhanced for visual reading. learn more >
Agglutination Tests: Types, principle and uses - microbeonlineAGGLUTINATION TESTS and IMMUNOASSYS

Agglutination Assays - Microbiolog

Staph Test Latex Reagent within 20 seconds. There must be no agglutina-tion with the Negative Control Latex Reagent. 2. Test a known negative strain such as S. epidermidis ATCC # 12228 or equiva-lent according to the test protocol. There must be no agglutination of the Staph Test Latex and Negative Control Latex Reagents within 20 seconds. 3 RF-Latex Test is a quick process of agglutination.An anti-antibody is the rheumatoid factor. The laboratory is able to detect this by its ability to bind and form clumps of latex or red blood cells containing human immunoglobulin G (IgG). If the rheumatoid factor is present in the patient's blood, it attaches the latex particles that cause.

Identification of Staphylococcus - YouTubeCross agglutination | definition of cross agglutination by

Agglutination Assays Microbiolog

Staph Rapid Latex Test Kit has been evaluated in comparison with a well-established commercially available latex agglutination test for S. aureus. 121 isolates of S. aureus and other closely related strains of Staphylococcus and a range of 56 potentially cross-reacting bacteria were tested in both products. Staph Rapid Latex Test Kit +ve -ve Tota This short animation demonstrates detection of specific antigens using the agglutination assay. This resource was developed by Cary Engleberg of the Universi.. For culture-negative meningitis, use of the latex agglutination test for detection of bacterial antigen in the CSF has a sensitivity of only 7%. Routine use of the latex agglutination test may not contribute to the management of suspected acute bacterial meningitis, since patients are treated on the basis of their clinical presentations and CSF findings Objectives: To know the incidence of bacterial meningitis in children below five years of age. To compare conventional culture and antigen detection methods ( Latex agglutination test). Materials and Methods: 100 CSF samples of clinically suspected meningitis cases in children below 5 years of age were included

Latex Agglutination Test - Virtual Interactive

Define latex agglutination test. latex agglutination test synonyms, latex agglutination test pronunciation, latex agglutination test translation, English dictionary definition of latex agglutination test. n. 1. The act or process of agglutinating; adhesion of distinct parts. agglutination - a clumping of bacteria or red cells when held. latex agglutination test: [ la´teks ] ( L. fluid ) 1. any of various white viscid fluids secreted by certain plants; the variety from Hevea brasiliensis, the rubber tree, was formerly the main source of commercial rubber. Allergic reactions to natural latex are an important cause of type IV hypersensitivity reactions . See also latex allergy.

It is an agglutination test. When the test serum (containing antinuclear antibodies) is brought into contact with latex particles coated with DNP (Deoxyribo nucleoprotein), agglutination of the latex particles takes place indicating a positive reaction. Requirements: Serum sample; SLE latex reagent; Positive and negative controls (PC; NC) Test car Latex agglutination test using recombinant antibody fragments. Following the immobilization of the scFv antibodies on the latex beads, the functionality of the sensitized particles was verified by combining equal amounts of antigen solutions with latex reagents on an agglutination card Co agglutination Test Agglutination test in which inert particles (latex beads or heat- killed S aureus Cowan 1 strain with protein A) are coated with antibody to any of a variety of antigens and then used to detect the antigen in specimens or in isolated bacteria.1/11/2013 Dr.T.V.Rao MD 52 52 HiStaph Latex Test Kit has been evaluated in comparison with a well established commercially available latex agglutination test for S. aureus. 121 isolates of S.aureus and other closely related strains of Staphylococcus and a range of 56 potentially cross-reacting bacteria were tested in both products. HiStaph Latex Test Kit +ve-veTota DISCUSSION. Of the 386 patients with pretreated bacterial or culture-negative meningitis in this report, latex agglutination did not identify a single bacterial pathogen not identified by CSF and/or blood culture. Of perhaps equal importance to clinicians, for patients with negative Gram stains, negative latex studies did not significantly lower the risk of bacterial meningitis Semi-Quantitative Agglutination Test. Agglutination tests can also be used to quantitate the level of antibodies to particulate antigens . In this test: one makes serial dilutions of a sample to be tested for antibody . and then adds a fixed number of red blood cells or bacteria or other such particulate antige